Protein name:
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1 ;
Alternative:
Phospholipase C-zeta-1 (PLC-zeta-1) ;Phosphoinositide phospholipase C-zeta-1 ;Testis-development protein NYD-SP27 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts via its C2 domain with PtdIns(3)P and, to a lesser extent, PtdIns(5)P in vitro.
Function:
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function.
Subcellular Location:
Nucleus
Cytoplasm
perinuclear region
Exhibits alternative cytoplasmic/nuclear localization during development. Translocates from the pronucleus into cytoplasm upon nuclear envelope breakdown for mitosis and localizes again to the pronucleus at interphase following meiosis and mitosis.
Protein Attributes:
50:
MEMRWFLSKI | QDDFRGGKIN | LEKTQRLLEK | LDIRCSYIHV | KQIFKDNDRL |
100:
KQGRITIEEF | RAIYRIITHR | EEIIEIFNTY | SENRKILLAS | NLAQFLTQEQ |
150:
YAAEMSKAIA | FEIIQKYEPI | EEVRKAHQMS | LEGFTRYMDS | RECLLFKNEC |
200:
RKVYQDMTHP | LNDYFISSSH | NTYLVSDQLL | GPSDLWGYVS | ALVKGCRCLE |
250:
IDCWDGAQNE | PVVYHGYTLT | SKLLFKTVIQ | AIHKYAFMTS | DYPVVLSLEN |
300:
HCSTAQQEVM | ADNLQATFGE | SLLSDMLDDF | PDTLPSPEAL | KFKILVKNKK |
350:
IGTLKETHER | KGSDKRGDNQ | DKETGVKKLP | GVMLFKKKKT | RKLKIALALS |
400:
DLVIYTKAEK | FKSFQHSRLY | QQFNENNSIG | ETQARKLSKL | RVHEFIFHTR |
450:
KFITRIYPKA | TRADSSNFNP | QEFWNIGCQM | VALNFQTPGL | PMDLQNGKFL |
500:
DNGGSGYILK | PHFLRESKSY | FNPSNIKEGM | PITLTIRLIS | GIQLPLTHSS |
550:
SNKGDSLVII | EVFGVPNDQM | KQQTRVIKKN | AFSPRWNETF | TFIIHVPELA |
600:
LIRFVVEGQG | LIAGNEFLGQ | YTLPLLCMNK | GYRRIPLFSR | MGESLEPASL |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Chicken
Mouse
Rat
Bovine
ELISA Kit for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
ELISA Kit for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
ELISA Kit for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
ELISA Kit for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
ELISA Kit for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
CLIA Kit for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
CLIA Kit for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
CLIA Kit for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
CLIA Kit for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
CLIA Kit for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Polyclonal Antibody for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Polyclonal Antibody for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Polyclonal Antibody for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Polyclonal Antibody for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Polyclonal Antibody for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Monoclonal Antibody for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Monoclonal Antibody for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Monoclonal Antibody for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Monoclonal Antibody for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Monoclonal Antibody for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Protein for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Protein for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Protein for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Protein for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Protein for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;TISSUE SPECIFICITY
tissue :
Testis .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);FUNCTION;TISSUE SPECIFICITY
tissue :
Testis .
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Nat. Genet.36:40-45(2004)
[
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[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Testis .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION